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Review

Frequently asked questions about managing cancer pain: An update

Renato V. Samala, MD, MHPE, FACP, FAAHPM, Ruth L. Lagman, MD, MPH, MBA, FACP, FAAHPM, Sina Najafi, DO and Flannery Fielding, CNP, MSN
Cleveland Clinic Journal of Medicine March 2021, 88 (3) 183-191; DOI: https://doi.org/10.3949/ccjm.88a.20107
Renato V. Samala
Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Ruth L. Lagman
Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Sina Najafi
Staff Physician, Supportive and Palliative Care, Baylor Scott & White Health, Dallas, TX
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Flannery Fielding
Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
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    Figure 1

    Our approach to managing cancer pain, based on the World Health Organization analgesic ladder.

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    TABLE 1

    Interventional procedures for cancer pain management

    Type of intervention or procedurePrimary tumor or metastatic site indications
    Nerve blocks
    Peripheral nerves
     Paravertebral ........................................................Chest-wall pain after mastectomy
     Interscalene .........................................................Upper-extremity pain after surgical repair of pathologic fractures and neuropathy from brachial plexoplathy
    Plexus nerves
     Celiac ...................................................................Right-upper-quadrant and epigastric pain from pancreaticobiliary malignancies
     Superior hypogastric ............................................Pelvic pain from gynecologic and urologic malignancies
     Ganglion impar ....................................................Perineal and rectal pain from anorectal and vulvar malignancies
    Implantable catheters and neuromodulation
    Intraspinal drug deliveryVisceral pain from abdominal malignancies, neuropathic pain for lower extremities, and intractable back pain from metastases
    Spinal cord stimulation
    Dorsal root ganglion stimulation
    Vertebral augmentation
    VertebroplastyBack pain from spine metastases and vertebral fractures
    Kyphoplasty
    Ablation procedures
    Radiofrequency ablationPain from metastatic bone and soft-tissues sites
    Cryoablation
    Microwave ablation
    Magnetic resonance imaging-guided focused-ultrasound surgery
    Transarterial embolization ..................................Pain from hypervascular bone metastases
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    TABLE 2

    Causes of chronic pain associated with cancer treatment

    Chemotherapy
    Peripheral neuropathy (with agents such as paclitaxel, docetaxel, vincristine, cisplatin, oxaliplatin, thalidomide, and bortezomib)
    Osteonecrosis secondary to concurrent steroid use
    Radiation therapy
    Connective-tissue fibrosis
    Neural damage (such as brachial plexopathy, myelopathy)
    Pain from secondary malignancies
    Enteritis
    Proctitis
    Cystitis
    Vaginal dryness or atrophy
    Surgery
    Mastectomy (may be due to phantom breast pain, intercostobrachial neuralgia, neuroma or nerve injury)
    Amputation or phantom limb pain
    Thoracotomy
    Head and neck surgery (eg, neck dissection)
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Cleveland Clinic Journal of Medicine: 88 (3)
Cleveland Clinic Journal of Medicine
Vol. 88, Issue 3
1 Mar 2021
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Frequently asked questions about managing cancer pain: An update
Renato V. Samala, Ruth L. Lagman, Sina Najafi, Flannery Fielding
Cleveland Clinic Journal of Medicine Mar 2021, 88 (3) 183-191; DOI: 10.3949/ccjm.88a.20107

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Frequently asked questions about managing cancer pain: An update
Renato V. Samala, Ruth L. Lagman, Sina Najafi, Flannery Fielding
Cleveland Clinic Journal of Medicine Mar 2021, 88 (3) 183-191; DOI: 10.3949/ccjm.88a.20107
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  • Article
    • ABSTRACT
    • WHAT ARE THE KEY PRINCIPLES IN MANAGING CANCER PAIN?
    • WHAT ARE SOME OF THE NONOPIOID MEDICATIONS USED FOR CANCER PAIN?
    • WHAT ARE SOME OF THE NEW OPIOID MEDICATIONS FOR CANCER PAIN?
    • WHAT IS THE ROLE OF RADIATION THERAPY IN MANAGING CANCER PAIN?
    • WHAT INTERVENTIONAL PROCEDURES ARE AVAILABLE FOR CANCER PAIN?
    • HOW IS PAIN MANAGED IN CANCER SURVIVORS?
    • A COMPREHENSIVE APPROACH TO A COMPLEX PROBLEM
    • DISCLOSURES
    • Acknowledgments
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