Interpreting Key Trials
The STAR*D study: Treating depression in the real world
Bradley N. Gaynes, MD, MPH, A. John Rush, MD, Madhukar H. Trivedi, MD, Stephen R. Wisniewski, PhD, Donald Spencer, MD, MBA and Maurizio Fava, MD
Cleveland Clinic Journal of Medicine January 2008, 75 (1) 57-66;
Bradley N. Gaynes
Associate Professor of Psychiatry, University of North Carolina School of Medicine; Investigator, Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study
A. John Rush
University of Texas Southwestern Medical Center at Dallas; Professor of Clinical Sciences and Psychiatry; Principal Investigator, STAR*D study
Madhukar H. Trivedi
University of Texas Southwestern Medical Center at Dallas; Professor of Psychiatry; National Coordinating Center, STAR*D study
Stephen R. Wisniewski
University of Pittsburgh School of Medicine; Associate Professor of Epidemiology; Data Coordinating Center, STAR*D study
Donald Spencer
University of North Carolina School of Medicine; Professor of Family Medicine; Investigator, STAR*D study
Maurizio Fava
Massachusetts General Hospital, Boston; Professor of Psychiatry; Investigator, STAR*D study

ABSTRACT
The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut “winner,” it does provide guidance on how to start therapy and how to proceed if initial treatment fails.
Footnotes
↵* The authors’ disclosures of potential conflicts of interest are listed at the end of this paper.
- Copyright © 2008 The Cleveland Clinic Foundation. All Rights Reserved.
In this issue
Cleveland Clinic Journal of Medicine
Vol. 75, Issue 1
1 Jan 2008
The STAR*D study: Treating depression in the real world
Bradley N. Gaynes, A. John Rush, Madhukar H. Trivedi, Stephen R. Wisniewski, Donald Spencer, Maurizio Fava
Cleveland Clinic Journal of Medicine Jan 2008, 75 (1) 57-66;
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