Table of Contents
From the Editor
- SGLT-2 inhibitors: Diabetes and CKD and CHF (and gout?), oh my!What mechanisms might account for the diverse beneficial effects of the SGLT-2 inhibitors observed across various diseases? 
The Clinical Picture
- Varicose veinsA 60-year-old man presented with a 20-year history of slowly worsening prominent veins in both lower limbs. 
1-Minute Consult
- Do patients with sepsis benefit from intravenous albumin?Patients with sepsis who do not need vasopressors do not benefit from intravenous albumin compared with intravenous crystalloid therapy alone. 
- Does my patient with acute variceal hemorrhage need a transjugular intrahepatic portosystemic shunt?Placement of a transjugular intrahepatic portosystemic shunt can be used as salvage therapy to control bleeding when endoscopic management fails and as a means of secondary prophylaxis in select patients. 
Review
- SGLT-2 inhibitors in heart failure and chronic kidney disease: A review for internistsThis review summarizes recent data and guidelines regarding SGLT-2 inhibitors in heart failure and chronic kidney disease and provides practical guidance for their use. 
- Lymphedema vs lipedema: Similar but differentLymphedema, lipedema, and even simple obesity in the extremities can resemble each other superficially and are often confused for one another, but they differ in important ways. 
- Preventing herpes zoster in immunocompromised patients: Current conceptsThe authors review clinical aspects of herpes zoster vaccination, including identifying at-risk patients, weighing the risks and benefits of the recombinant zoster vaccine, and using best practices for administering the vaccine. 




