Oral immunotherapy: The answer to peanut allergy?

Rachel M. Whitsel; Jaclyn A. Bjelac; Ahila Subramanian; Alice E. W. Hoyt; Sandra J. Hong

doi:10.3949/ccjm.88a.20130

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Oral immunotherapy: The answer to peanut allergy?

Rachel M. Whitsel, APRN, Jaclyn A. Bjelac, MD, Ahila Subramanian, MD, Alice E. W. Hoyt, MD and Sandra J. Hong, MD

Cleveland Clinic Journal of Medicine February 2021, 88 (2) 104-109; DOI: https://doi.org/10.3949/ccjm.88a.20130

Rachel M. Whitsel

Department of Allergy and Clinical Immunology, Food Allergy Center of Excellence., Cleveland Clinic

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Jaclyn A. Bjelac

Department of Pediatric Allergy and Clinical Immunology, Food Allergy Center of Excellence, Cleveland Clinic; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

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Ahila Subramanian

Department of Allergy and Clinical Immunology, Food Allergy Center of Excellence, Cleveland Clinic

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Alice E. W. Hoyt

Department of Allergy and Clinical Immunology, Food Allergy Center of Excellence, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

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Sandra J. Hong

Department of Allergy and Clinical Immunology, Food Allergy Center of Excellence, Cleveland Clinic; Clinical Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

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For correspondence: [email protected]
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TABLE 1

Protocol for the peanut-derived oral immunotherapy agent

Phase	Duration	Dosage
Dose-escalation	Single day	5 levels: 0.5, 1, 1.5, 3, and 6 mg; increasing doses every 20–30 minutes
Up-dosing	Months	11 levels: 3, 6, 12, 20, 40, 80, 120, 160, 200, 240, and 300 mg daily; increasing doses at visits every 2 weeks
Maintenance	Months to years	300 mg daily

Adapted from information in reference 15.

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Cleveland Clinic Journal of Medicine

Vol. 88, Issue 2

1 Feb 2021

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