Table of Contents
Medical Grand Rounds
- Diagnosing infective endocarditisThe diagnosis has been based on the presence of fever, a new heart murmur, peripheral stigmata, and sustained bacteremia with a typical microorganism—all of which are not invariably present. New criteria offer greater diagnostic accuracy. 
- Assessing depression in medical patientsSuicidal ideation is an intensely personal matter, and many patients may be alarmed by questions about it. A less threatening approach is described. 
Internal Medicine Board Review
Clinical Applications of Research
- Preglomerular and postglomerular blood flow: relationship to kidney disease and treatmentClinicians are taking the first steps toward preventing or slowing kidney failure, thanks to special techniques for studying renal microcirculation. 
Reviews
- Prophylaxis of opportunistic infections in persons with HIV infectionEffective regimens are available for preventing some of these infections. Studies are in progress to establish optimum regimens for others. 
- Chemotherapy-induced Raynaud's phenomenonCure of malignancy is most important, but detecting delayed toxic effects of antineoplastic therapy deserves close attention, as well. 
Original Studies
- Metastasis or adenoma? CT evaluation of the adrenal massDocumenting the stability of adrenal lesions should be done for longer than usual to increase the likelihood of identifying malignant adenomas. 
- Azathioprine vs cyclosporine in recipients of HLA-identical renal allograftsThese two agents produce equally satisfactory outcomes in this immunologically favored group. The need for continued steroid therapy in these patients requires further study. 
Cardiology Dialogues
- Transesophageal echocardiography: why and when to use itIn this open discussion of an important health care utilization issue, panelists expound on the appropriateness of TEE in several clinical situations. 
Clinical Pathological Conference
- A 51-year-old man with a history of stroke and red streaks in the legsA diagnostically challenging case is worked up. Based on a presentation at a Cleveland Clinic Foundation Clinical Pathological Conference. 
Case Reports
Editorial
- Clinical practice guidelines for HIV infection: progress towards making AIDS a primary care diseaseAn appraisal of the guidelines released in January by the Agency for Health Care Policy and US Public Health Service. 



