TABLE 2

Recommendations for measuring biomarkers in heart failure

Patient group	Class^a
At risk of heart failure
BNP or NT-proBNP for prevention	IIa
Ambulatory with new-onset dyspnea
BNP or NT-proBNP for diagnosis	I
With NYHA class II-IV symptoms
BNP or NT-proBNP for prognosis	I
Other biomarkers of myocardial injury or fibrosis^b for prognosis	IIb
With acute dyspnea in the emergency department
BNP or NT-proBNP for diagnosis	I
BNP or NT-proBNP, and cardiac troponin for prognosis	I
Hospitalized for acute decompensated heart failure
BNP or NT-proBNP, and cardiac troponin for prognosis	I
BNP or NT-proBNP before discharge for prognosis	IIa
Other biomarkers of myocardial injury or fibrosis^b for prognosis	IIb

↵a Class of recommendation (I strong, Ila moderate, Ilb weak).
↵b For example, soluble ST2 receptor, galectin-3, and high-sensitivity troponin.
BNP = B-type natriuretic peptide; NT-proBNP = N-terminal pro-B-type natriuretic peptide; NYHA = New York Heart Association
Information from reference 1.