Cutaneous adverse effects of small-molecule tyrosine kinase inhibitors
| Examples | Adverse effects | Management strategies |
|---|---|---|
| Axitinib Bosutinib Dabrafenib Dasatinib Dovitinib Imatinib Nilotinib Pazopanib Ponatinib Ruxolitinib Sorafenib Sunitinib Vandetanib Vemurafenib | Rash (exanthematous papular eruption) | Discontinue and then reintroduce at lower dose, temporary course of oral corticosteroid |
| Hand-foot skin reactions | Topical emollients, topical urea, salicylic acid, topical corticosteroid | |
| Keratoacanthoma, squamous cell carcinoma | Phototherapy, intralesional methotrexate, retinoids and excision | |
| Acneiform eruption | Topical antiseptics and antibiotics, oral antibiotics, systemic isotretinoin, short course of a low-dose systemic corticosteroid |