Cutaneous adverse effects of cell surface-targeted monoclonal antibodies
| Examples | Adverse effects | Management strategies |
|---|---|---|
| Anakinra Avelumab Ipilimumab Nivolumab Pembrolizumab Rituximab Tocilizumab Tofacitinib | Infusion reactions | Premedicate with acetaminophen and diphenhydramine 30 minutes before the first and second infusions |
| Serum sickness | Pulse methylprednisolone therapy | |
| Stevens-Johnson syndrome/toxic endothelial necrolysis and vesiculobullous dermatitis | Discontinue therapy | |
| Rash (lichenoid, bullous, psoriasiform, macular, morbiliform morphologies) | Topical corticosteroids, systemic steroids |