Indications to initiate treatment for chronic lymphocytic leukemia
| Constitutional symptoms attributable to the disease |
| Progressive marrow failure |
| Autoimmune anemia or thrombocytopenia poorly responsive to corticosteroids |
| Massive or progressive splenomegaly |
| Massive or progressive lymphadenopathy |
| Rapid lymphocyte doubling time |
Based on information in reference 30.