Thrombotic thrombocytopenic purpura vs hemolytic uremic syndrome
| Thrombotic thrombocytopenic purpura | Hemolytic-uremic syndrome | |
|---|---|---|
| Ischemia, tissue injury | Multiorgan | Renal |
| Presentation in children | Few cases (early onset of congenital TTP) | Most cases; usually accompanied by bloody diarrhea (except in atypical hemolytic-uremic syndrome) |
| ADAMTS13 activity | Markedly reduced | Normal or mildly reduced in almost all cases |
| Recurrence | Common | Rare |
| Therapeutic plasma exchange | Good response | Poor response when associated with Escherichia coli infection |
| May help in atypical hemolytic uremic syndrome | ||
| Sequelae | Approximately 80% of patients showing complete response without sequelae | Permanent renal damage in 30% (rate higher in atypical hemolytic uremic syndrome) |