Hormone therapy: Contraindications and precautions
| Contraindications. In general, estrogen therapy should not be used in women with any of the following conditions: |
| Undiagnosed abnormal genital bleeding |
| Known, suspected, or history of cancer of the breast |
| Known or suspected estrogen-dependent neoplasia including endometrial cancer |
| Active deep vein thrombosis, pulmonary embolism, or history of these conditions |
| Active arterial thromboembolic disease (for example, stroke, myocardial infarction) or a history of these conditions |
| Known anaphylactic reaction or angioedema in response to any ingredient in the medication |
| Known liver impairment or disease |
| Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders |
| Known or suspected pregnancy |
| Caution should also be exercised in women with: |
| Gallbladder disease (oral estrogen therapy) |
| Hypertriglyceridemia (> 400 mg/day) (oral estrogen therapy) |
| Diabetes |
| Hypoparathyroidism (risk of hypocalcemia) |
| Benign meningioma |
| Intermediate or high risk of breast cancer |
| High risk of heart disease |
| Migraine with aura (can be used, but may exacerbate condition) |
| Asthma (rare chance of exacerbation) |
| Epilepsy |
| Porphyria |
| Systemic lupus erythematosus |
| Hepatic hemangioma |
Based on information in reference 3.