The Dutch Lipid Clinic Network diagnostic criteria for familial hypercholesterolemia
| Criteria | Points |
|---|---|
| Family history | |
| First-degree relative with known premature atherosclerotic cardiovascular disease (age < 55 in men, age < 60 in women) or first-degree relative with LDL-C > 95th percentile | 1 |
| First-degree relative with tendon xanthomas or arcus cornealis, or child under age 18 with LDL-C > 95th percentile | 2 |
| Clinical history | |
| Premature coronary artery disease | 2 |
| Premature cerebral or peripheral vascular disease | 1 |
| Physical examination | |
| Tendon xanthomas | 6 |
| Arcus cornealis before age 45 | 4 |
| LDL-C levels, mg/dL | |
| ≥ 330 | 8 |
| 250–329 | 5 |
| 190–249 | 3 |
| 155–189 | 1 |
| DNA analysis | |
| Functional mutation in the LDLR, APOB, or PCSK9 gene | 8 |
| Interpretation | Total |
| Definite familial hypercholesterolemia | > 8 |
| Probable familial hypercholesterolemia | 6–8 |
| Possible familial hypercholesterolemia | 3–5 |
| Unlikely familial hypercholesterolemia | < 3 |
From the World Health Organization, reference 24.