Risk factors for radiation-induced heart disease
| Anterior or left chest irradiation location |
| High cumulative dose of radiation (> 30 Gy) |
| Younger age (< 50) at time of radiation therapy |
| High dose of radiation fractions (> 2 Gy/day) |
| Presence and extent of tumor in or next to the heart |
| Inadequate or absent shielding |
| Concomitant chemotherapy (eg, anthracyclines) |
| Cardiovascular risk factors |
| Preexisting cardiovascular disease |