Clinical manifestations of acromegaly
| Neurologic symptoms due to pituitary tumor’s mass effect Visual field deficits, headache, cranial nerve palsies |
| Musculoskeletal system Increased thickness of soft tissue of hands and feet (enlarging size of gloves and shoes, rings becoming too small), prognathism, jaw malocclusion, arthropathy and osteoarthritis (affects up to 75% of patients and is a leading cause of morbidity and disability in patients with acromegaly), carpal tunnel syndrome (present in about 64% of patients on presentation), proximal myopathy, hypertrophy of frontal bones (frontal bossing) |
| Integumentary system Oily texture, hyperhidrosis, skin tags, deep skin creases |
| Cardiovascular system Biventricular hypertrophy, asymmetric septal hypertrophy, cardiomyopathy, congestive heart failure, diastolic heart failure, arrhythmias (up to 40% of patients develop conduction disorders), hypertension |
| Respiratory system Obstructive sleep apnea |
| Gastrointestinal system Colon polyps, colon cancer, macroglossia, hepatomegaly |
| Endocrine and metabolic system Irregular menses, galactorrhea, decreased libido, erectile dysfunction, thyromegaly, diabetes mellitus, hypertriglyceridemia; in multiple endocrine neoplasia syndrome 1, acromegaly may be associated with primary hyperparathyroidism and pancreatic islet tumors. |
Based on information from references 2 and 3.