When to interrupt direct oral anticoagulants: A simplified approach
| Direct oral anticoagulant | Surgery or procedure bleeding risk | |
|---|---|---|
| Low | High | |
| Dabigatran | ||
| (creatinine clearance ≥ 50 mL/min) | 1 day off | 2 days off |
| (creatinine clearance < 50 mL/min) | 2 days off | 4 days off |
| Rivaroxaban | 1 day off | 2 days off |
| Apixaban | 1 day off | 2 days off |
| Edoxaban | 1 day off | 2 days off |
| No direct oral anticoagulant on day of surgery or procedure | ||
Based on information in reference 26.