When to interrupt direct oral anticoagulants based on drug pharmacokinetics
| Direct oral anticoagulant | Drug half-life | Renal clearance | Days before surgery |
|---|---|---|---|
| Apixaban | 9–12 hours | 25% | 2 |
| Dabigatran | |||
| (creatinine clearance ≥ 50 mL/min) | 12–14 hours | 80% | 2 |
| (creatinine clearance < 50 mL/min) | 18–24 hours | 80% | 4 |
| Rivaroxaban | 8–12 hours | 33% | 2 |
| Edoxaban | 10–14 hours | 50% | 2 |