Designer estrogens and their uses
| Agent | Approved uses | Other possible benefits | Adverse effects |
|---|---|---|---|
| Tamoxifen | To treat metastatic breast cancer and ductal carcinoma in situ To reduce the risk of estrogen receptor-positive breast cancer in women at high risk | Positive effect on bone Positive effect on cardiovascular risk | Venous thromboembolism Uterine neoplasia Vasomotor symptoms |
| Raloxifene | To prevent and treat osteoporosis To reduce the risk of invasive estrogen receptor-positive breast cancer in postmenopausal women | Reduction in breast cancer risk | Venous thromboembolism Stroke |
| Ospemifene | To treat genitourinary syndrome of menopause | Positive effect on bone | Venous thromboembolism |
| Conjugated estrogen-bazedoxifene | In women with a uterus: to prevent osteoporosis and treat vasomotor symptoms of menopause | Positive effects on uterus, genitourinary syndrome of menopause | Venous thromboembolism |