Liver disease and associated liver enzyme elevations
| Hepatocellular disease (aminotransferase elevations predominate) |
| Common Alcoholic liver disease Autoimmune hepatitis Chronic viral hepatitis Genetic hemochromatosis (northern European ethnicity) Medication toxicity (see Table 2) Nonalcoholic fatty liver disease |
| Less common Alpha-1 antitrypsin deficiency Wilson disease |
| Cholestatic disease (alkaline phosphatase, bilirubin, and gammaglutamyl transferase elevations predominate) |
| Common Biliary obstruction (eg, gallstones) Drug hepatotoxicity Neoplasm Primary biliary cirrhosis Primary sclerosing cholangitis |
| Less common Autoimmune cholangiopathy Sarcoidosis |
From Aragon G, Zounossi ZM. When and how to evaluate mildly elevated liver enzymes in apparently healthy patients. Cleve Clin J Med 2010; 77(3):195–204. doi:10.3949/ccjm.77a.09064.