Key drug interactions with calcineurin inhibitors and sirolimus
| Increase levels of cyclosporine, tacrolimus, sirolimus |
| Clarithromycin |
| Erythromycin |
| Azole antifungals |
| Diltiazem |
| Verapamil |
| Isoniazid |
| Protease inhibitors |
| Grapefruit |
| Reduce levels of cyclosporine, tacrolimus, sirolimus |
| Rifampin |
| Phenytoin |
| Carbamazepine |
| Phenobarbital |
| Nevirapine |
| St. John’s wort |