Direct oral anticoagulant use in extreme body weight
| Condition | Body mass index or weight | ||
|---|---|---|---|
| ≥ 50 kg/m2 or > 150 kg | 40–49 kg/m2 or 120–150 kg | < 18.5 kg/m2 or < 60 kg | |
| Venous thromboembolism | Data limited | Apixaban and rivaroxaban may preferably be used | Data scarce, but DOACs may be used |
| Atrial fibrillation | Data limited | Apixaban, rivaroxaban, and dabigatran can be used | Apixaban is preferred; reduce dose to 2.5 mg twice daily if creatinine clearance > 1.5 mg/dL or age > 80, or both; other DOACs may also be considered |
Based on information from references 3 and 17.