TABLE 4

Proposed approach for Helicobacter pylori eradication therapy incorporating vonoprazan

		Preferred regimens	Alternative regimens
Antimicrobial susceptibility information not available	Clarithromycin resistance < 15%	Vonoprazan triple therapy^{^a}	Vonoprazan dual therapy^{^b} Clarithromycin triple therapy Bismuth quadruple therapy
Antimicrobial susceptibility information not available	Clarithromycin resistance ≥ 15%	Bismuth quadruple therapy	Vonoprazan dual therapy^{^b}
Antimicrobial susceptibility information available	Clarithromycin susceptible	Clarithromycin or vonoprazan triple therapy^{^a}	Vonoprazan dual therapy^{^b}
	Metronidazole susceptible	Metronidazole triple therapy	Vonoprazan dual therapy^{^b}
	Levofloxacin susceptible	Levofloxacin triple therapy	Vonoprazan dual therapy^{^b} Bismuth quadruple therapy