TABLE 4

Summary of patients with acquired hemophilia A and thrombosis

Study	Risk factors for thrombosis	At diagnosis			Hematologic treatment	Immunosuppression regimen
Study	Risk factors for thrombosis	Activated partial thromboplastin time, seconds	Factor VIII, U/dL	Inhibitor, Bethesda units/mL	Hematologic treatment	Immunosuppression regimen
1. Poli et al¹⁸	Pregnancy	57 at deep vein thrombosis diagnosis and on anticoagulation	1.9	NA	Vitamin K	Prednisone 1 g/kg/day (4 weeks)
2. Deitcher et al¹⁹	Idiopathic	54.3 (24–33)	5.3	57	Factor VIII concentrate and desmopressin	NA
	Lymphoma	61.4 (22–33)	2	47	Factor VIII concentrate and desmopressin	NA
	Postoperative	54.8 (22–33)	2	5	Factor VIII concentrate and desmopressin	NA
3. Spencer et al²⁰	Pregnancy	3.01	2	35	Recombinant activated factor VII	Prednisolone 1 mg/kg/day (6 weeks) and cyclophosphamide 100 mg/day (6 months)
4. Paudel et al²¹	Trauma or surgery	> 100	< 1	12	Vitamin K, fresh frozen plasma, recombinant activated factor VII	Methylprednisolone 120 mg/day, then rituximab 375 mg/m²/weekly for 4 doses
5. Wool et al²²	Idiopathic	76.9 (24–34)	4	27	Factor VIII concentrate (2 days), then recombinant activated factor VII (30 μg/kg/dose), then therapeutic plasma exchange	Dexamethasone 8 mg/12 hours, therapeutic plasma exchange days 5 and 6, then rituximab 375 mg/m²/week (2 doses)
6. Maral et al²³	Malignancy	107 (22–34)	3	350	NA	Prednisolone 1 mg/kg/day and cyclophosphamide 500 mg/week
7. Chhabra et al²⁴	Idiopathic	78.6	< 1	82	Recombinant activated factor VII	Prednisolone 1 mg/kg/day and cyclophosphamide 100 mg/day
8. Aslam et al²⁵	Addison disease	81.8	< 6	NA	Activated prothrombin complex concentrate, vitamin K	Intravenous methylprednisolone 30 mg/12 hours

NA = not available