Effect of various treatments on functional dyspepsia
| Treatmenta | Effect on postprandial distressb | Effect on epigastric painb |
|---|---|---|
| Antisecretory agents | ||
| Famotidine17 | ++ ++ | |
| Proton pump inhibitors10,20 | ++ ++ | |
| Neuromodulators | ||
| Buspirone23,24 | ++ | 0 |
| Mirtazapine25 | ++ | 0 |
| Amitriptyline26 | 0 | ++ |
| Escitalopram26 | 0 | + |
| Gabapentin27 | + | NA |
| Pregabalin28 | ++ | ++ |
| Prokinetic therapy | ||
| Metoclopramide29 | ++ | ++ |
| Antibiotics | ||
| Rifaximin30 | ++ | ++ |
| Complementary and alternative medicine | ||
| STW 531 | NA | NA |
| Caraway and L-menthol32 | ++ | ++ |
| Capsaicin33 | ++ | ++ |
| Acupuncture34 | + | + |
| Hypnotherapy35 | NA | + |
↵a All treatments are off-label. No treatment for functional dyspepsia has yet been approved by the US Food and Drug Administration.
↵b Qualitative estimates of effect are based on experience and the studies summarized in the text: 0 = no effect, + = some effect, ++ = moderate effect, +++ = strong effect.
NA = information not available