Risk factors for major bleeding on anticoagulation
| Age greater than 75 |
| Recent major bleeding, ie, requiring transfusion of 2 or more units of blood; retroperitoneal, spinal, or intracranial bleeding |
| Severe liver dysfunction (baseline abnormal prothrombin time) |
| Severe renal impairment (creatinine clearance rate < 30 mL/min) |
| Severe thrombocytopenia (platelet count < 50 × 109/L) |
| Cancer |
| Acute hemorrhagic stroke or cerebral lesions at high risk of bleeding |
| Severe uncontrolled hypertension |
Based on information in references 1, 8, 11, 13, and 14.