Contraindications to hormone therapy
| Contraindications | Pertinent considerations |
|---|---|
| Prior history of coronary heart disease, stroke, myocardial infarction, or unprovoked venous thromboembolism or inherited high risk of thromboembolic disease, or significantly high risk for cardiovascular disease | Relative contraindication: hormone therapy can be considered on a case-by-case basis |
| Unexplained vaginal bleeding | Relative contraindication: unexplained vaginal bleeding should be evaluated before hormone therapy is considered |
| End-stage liver disease | Relative contraindication: hormone therapy can be considered on a case-by-case basis |
| Prior history of estrogen-receptor-positive cancer | Absolute contraindication |