Findings that may warrant cardiac amyloidosis workup
| Extracardiac manifestations | Cardiac manifestations | Imaging findings |
|---|---|---|
| Bilateral carpal tunnel syndrome | Persistent mildly elevated troponin levels | Echocardiography: increased thickness of left ventricle, right ventricular free wall, atrioventricular valves, interatrial septum |
| Unprovoked biceps tendon rupture | Symptomatic hypotension or orthostasis in response to hypertensive medication | Electrocardiography: discrepancy in QRS voltage and left ventricular thickness |
| Lumbar stenosis | Unexplained atrioventricular block, heart block, or bundle branch block | Strain echocardiography: longitudinal impairment with apical sparing |
| Sensorimotor polyneuropathy | Elevated N-terminal-pro-brain natriuretic peptide not proportionate to severity of heart failure | Cardiac magnetic resonance imaging: increased extracellular volume or late enhancement |
| Autonomic dysfunction | Family history of cardiomyopathy | Chest radiography: cardiomegaly |