TABLE 2

An overview of tumor pathology in hereditary breast cancer

Gene with pathogenic variantEstrogen-receptor–positive tumorEstrogen-receptor–negative tumorTriple-negative tumor
BRCA1Increasingly positive after age 50+++ particularly before age 50+++ particularly before age 50
BRCA2++Over-representation,a but still primarily estrogen-receptor–positiveOver-representation,a but still primarily estrogen-receptor–positive
PALB2++Over-representation,a but still primarily estrogen-receptor–positiveOver-representation,a but still primarily estrogen-receptor–positive
ATM+++
CHEK2+++
CDH1+++
TP53+++
BARD1++++++
RAD51C++++++
RAD51D++++++

  • ↵a Estrogen receptor tumors are more common than in the general population but are still not the predominant type of tumor pathology.

  • + = relative prevalence