TABLE 1

Esophageal adenocarcinoma vs squamous cell carcinoma

AdenocarcinomaSquamous cell carcinoma
Proportion of esophageal cancersa64%29%
Risk factorsBarrett esophagus
Gastroesophageal reflux disease
Central obesity
Age > 50
Male sex		Heavy alcohol consumption
Smoking
Hot tea consumption
Nitrite consumption
Head and neck cancer
Tylosis (autosomal dominant syndrome, mutation in RHBDF2 gene)

  • ↵a Based on 2018 data from National Cancer Institute Surveillance, Epidemiology, and End Results Program, reference 2.