Risk of antidepressant discontinuation syndrome (ADS): A summary of antidepressant dosing
| Risk of ADS | Name (brand name) | Starting daily dose (mg) | Daily dose range (mg) | Typical dose increment (mg) (conservative dose increment) |
|---|---|---|---|---|
| Low | Bupropion XL (Wellbutrin XL)a | 150 | 150–450 | 150 |
| Doxepin (Silenor) | 3 | 3–6 | 3 | |
| Fluoxetine (Prozac)a | 10 | 10–80 | 10 | |
| Levomilnacipran (Savella) | 20 | 20–120 | 40 (20) | |
| Milnacipran (Fetzima) | 25 | 50–300 | 25–50 (12.5) | |
| Vilazodone (Viibryd) | 10 | 10–40 | 10 | |
| Citalopram (Celexa) | 10 | 10–40 | 10 | |
| Escitalopram (Lexapro) | 5 | 5–30 | 10 (5) | |
| Mirtazapine (Remeron) | 7.5–15 | 7.5–60 | 15 (7.5) | |
| Intermediate | Sertraline (Zoloft) | 25 | 25–300 | 50 (12.5–25) |
| Trazodone (Deseryl) | 25–50 | 25–400 | 50 (25) | |
| Vortioxetine (Trintellix) | 5 | 5–20 | 5 | |
| Amitriptyline (Elavil) | 10–25 | 10–300 | 50 (10–25) | |
| Clomipramine (Anafranil) | 25 | 25–300 | 50 (25) | |
| Desipramine (Norpramin) | 25 | 25–300 | 25–50 (10–25) | |
| Desvenlafaxine (Pristiq) | 25 | 50–400 | 50 (25) | |
| Doxepin (Sinequan) | 25 | 25–300 | 25–50 (10–25) | |
| Duloxetine DR (Cymbalta DR) | 20–30 | 30–120 | 30 (20) | |
| High | Fluvoxamine (Luvox)b | 25 | 25–300 | 50 (12.5–25) |
| Imipramine (Tofranil) | 25 | 25–300 | 25–50 (10–25) | |
| Nortriptyline (Pamelor) | 10–50 | 10–150 | 25–50 (10–25) | |
| Paroxetine (Paxil)a | 10 | 10–50 | 10 (5) | |
| Phenelzine (Nardil) | 15 | 7.5–90 | 15 | |
| Tranylcypromine (Parnate) | 10 | 10–60 | 10 | |
| Venlafaxine ER (Effexor ER) | 37.5 | 75–375 | 37.5 | |