Randomized controlled trials evaluating early goal-directed care in septic shock
| Author and year | Number of patients | Major findings |
|---|---|---|
| Rivers et al,61 2001 | 268 | Significantly lower mortality rate with protocolized care |
| Peake et al,82 2014 | 1,600 | No reduction in mortality, need for advanced respiratory or renal support, or intensive care unit length of stay with protocolized care |
| Rowan et al,85 2014 | 1,351 | No reduction in mortality, need for advanced respiratory or renal support, or intensive care unit length of stay with protocolized care |
| Mouncey et al,83 2015 | 1,260 | No reduction in mortality, need for advanced respiratory, cardiovascular or renal support, or intensive care unit length of stay with protocolized care |