Positive thresholds of biochemical testing for primary aldosteronism
| Screening tests | More conservative | Most widely accepted | More liberal | |
|---|---|---|---|---|
| Aldosterone-renin ratio (ng/dL per ng/mL/hour) | ≥ 40 | ≥ 30 | ≥ 20 | |
| Plasma aldosterone concentration (ng/dL) | ≥ 20 | ≥ 15 | ≥ 10 | |
| Confirmation aldosterone suppression tests | More conservative | More liberal | ||
| With oral salt | ||||
| 24-Hour urinary aldosterone excretion rate (μg) | > 12–14 | > 10 | ||
| With intravenous saline | ||||
| Plasma aldosterone concentration (ng/dL) | > 10 | > 5 | ||
| With fludrocortisone | ||||
| Seated plasma aldosterone concentration (ng/dL) | > 6 | |||
| with plasma renin activity | ||||
| < 1 ng/mL/hour | ||||
| With captopril | ||||
| Plasma aldosterone concentration, | < 30% | |||
| decrease from baseline | ||||
| Aldosterone-renin ratio (ng/dL per ng/mL/hour) | > 30 | > 20 | ||
Based on information in references 2 and 11.