Failure criteria for noninvasive ventilation (NIV) and high-flow nasal cannula (HFNC)
| NIV Failure Criteria |
| • Tidal volume > 9.5 mL/kg/IBW consistently over the first 4 hours |
| • FiO2 > 60% to maintain target SpO2 |
| HFNC Failure Criteria |
| • ROX scorea ≥ 4.88 at 2, 6 and 12 hrs is a good predictor of no need for intubation and < 3.85 is high risk for need for intubation |
↵a ROX score = (SpO2/FiO2)/RR.