PT  - JOURNAL ARTICLE
ED  - Vidt, Donald G.
ED  - Bakst, Alan
AU  - Bolwell, Brian J.
TI  - The use of G-CSF and GM-CSF in bone marrow transplantation
DP  - 1993 Jul 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 291--302
VI  - 60
IP  - 4
4099  - http://www.ccjm.org/content/60/4/291.short
4100  - http://www.ccjm.org/content/60/4/291.full
SO  - Cleve Clin J Med1993 Jul 01; 60
AB  - Bone marrow transplantation is accepted as potentially curative therapy for a variety of patients with hematologic malignancies and other disorders. The most important causes of morbidity are infections and bleeding secondary to prolonged cytopenias. Granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) have been shown to potentially enhance bone marrow engraftment which has translated into reduced morbidity and mortality. Additionally, growth factors such as G-CSF and GM-CSF may increase numbers of circulating peripheral progenitor cells to serve as the source of "marrow" for transplantation. This review summarizes the current available data using G-CSF and GM-CSF in bone marrow transplantation and discusses potential areas of study with additional cytokines.