PT  - JOURNAL ARTICLE
AU  - Depta, Jeremiah P.
AU  - Bhatt, Deepak L.
TI  - Omeprazole and clopidogrel: Should clinicians be worried?
AID  - 10.3949/ccjm.77a.09173
DP  - 2010 Feb 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 113--116
VI  - 77
IP  - 2
4099  - http://www.ccjm.org/content/77/2/113.short
4100  - http://www.ccjm.org/content/77/2/113.full
SO  - Cleve Clin J Med2010 Feb 01; 77
AB  - The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor.