PT - JOURNAL ARTICLE AU - VillaseƱor-Park, Jennifer AU - Wheeler, David AU - Grandinetti, Lisa TI - Psoriasis: Evolving treatment for a complex disease AID - 10.3949/ccjm.79a.11133 DP - 2012 Jun 01 TA - Cleveland Clinic Journal of Medicine PG - 413--423 VI - 79 IP - 6 4099 - http://www.ccjm.org/content/79/6/413.short 4100 - http://www.ccjm.org/content/79/6/413.full SO - Cleve Clin J Med2012 Jun 01; 79 AB - The cutaneous manifestations of psoriasis can vary in morphology and severity, and therapy should be tailored accordingly. Biologic agents are important new options for treating patients with the most severe forms of the disease. All physicians should be aware that severe psoriasis may increase cardiovascular morbidity and the risk of death, and preventive strategies for patients with severe disease should be considered.