Latest Articles

  • A young man with hypertension and hypokalemia
    Zainah Chiko, BSHS, Mohamad Hanouneh, MD and C. John Sperati, MD, MHS
    Cleveland Clinic Journal of Medicine February 2020, 87 (2) 77-79; DOI: https://doi.org/10.3949/ccjm.87a.19111

    At presentation, his blood pressure was 184/154 mm Hg, and his serum potassium level was 3.1 mmol/L.

  • Familial hypercholesterolemia: Detect, treat, and ask about family
    Familial hypercholesterolemia: Detect, treat, and ask about family
    Nishant P. Shah, MD, Haitham M. Ahmed, MD, MPH and W. H. Wilson Tang, MD
    Cleveland Clinic Journal of Medicine February 2020, 87 (2) 109-120; DOI: https://doi.org/10.3949/ccjm.87a.19021

    Patients can develop elevated LDL-C and atherosclerotic cardiovascular disease at a young age.

  • Pharmacogenomics: An evolving clinical tool for precision medicine
    Jennifer K. Hockings, PharmD, PhD, Amy L. Pasternak, PharmD, Angelika L. Erwin, MD, PhD, Neil T. Mason, MBA, Charis Eng, MD, PhD and J. Kevin Hicks, PharmD, PhD
    Cleveland Clinic Journal of Medicine February 2020, 87 (2) 91-99; DOI: https://doi.org/10.3949/ccjm.87a.19073

    More than 90% of patients are thought to carry at least 1 genetic variant that should prompt a change in dosing or medication.

  • The search for precision
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine February 2020, 87 (2) 71-72; DOI: https://doi.org/10.3949/ccjm.87b.02020

    The day may come soon when we get EMR alerts if we try to prescribe certain drugs to patients with certain gene variants.

  • Are we all clear? Unintended shocks to caregivers during cardiopulmonary resuscitation
    David R. Lowery, MD, FASA, Maj, MC, USA, Daniel Cantillon, MD, FACC, FHRS and Donn Marciniak, MD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 16-18; DOI: https://doi.org/10.3949/ccjm.87a.19022

    Defibrillators are designed to affect electrical activity in the patient’s heart. Caregivers, be careful!

  • Modifying genetic diseases: Promises to be realized?
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 7-8; DOI: https://doi.org/10.3949/ccjm.87b.01020

    Genetic engineering offers hope to patients and families who previously had little.

  • Sickle cell disease: A primary care update
    Grace Onimoe, MD and Seth Rotz, MD
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 19-27; DOI: https://doi.org/10.3949/ccjm.87a.18051

    Survival has improved, but patients still face multiorgan damage, chronic anemia, and debilitating pain crises.

  • Cardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancy
    Cardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancy
    Kayle S. Shapero, MD, PhD, Nihar R. Desai, MD, MPH, Robert W. Elder, MD, Heather S. Lipkind, MD, Josephine C. Chou, MD, MS and Erica S. Spatz, MD, MHS
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 43-52; DOI: https://doi.org/10.3949/ccjm.87a.18137

    Pregnancy can exacerbate known cardiovascular disorders and unmask previously unrecognized problems.

  • In reply: Is diabetes still a compelling indication for renin-angiotensin-aldosterone system inhibitors?
    Sunil Bhandari, MBChB, FRCP, PhD, M Clin Edu, FHEA, Tasnim Momoniat, MBChB, MRCP (UK) and Duha Ilyas, MBBS, MRCP (UK)
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 9-10; DOI: https://doi.org/10.3949/ccjm.87c.01002
  • Sepsis and septic shock: Guideline-based management
    Siddharth Dugar, MD, Chirag Choudhary, MD, MBA and Abhijit Duggal, MD, MPH, MSc, FACP
    Cleveland Clinic Journal of Medicine January 2020, 87 (1) 53-64; DOI: https://doi.org/10.3949/ccjm.87a.18143

    Sepsis requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection.

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