Latest Articles
- Managing knee osteoarthritis before and after arthroplasty
Primary care physicians play a key role in the diagnosis and nonoperative management of knee osteoarthritis, including monitoring for problems in patients who have undergone knee replacement surgery.
- Interpreting the Courage Trial
We are fortunate to have a point-counterpoint between Dr. William Boden, the principal investigator of the Clinical Outcomes Utilizing Percutaneous Coronary Revascularization and Aggressive Drug Evaluation (COURAGE) trial, and Dr. Dean Kereiakes, a leading interventional cardiologist.
- The art and evidence of medical practice
A message from the Spine Patient Outcomes Research Trial (SPORT) could be that the artful judgment of a seasoned clinician, with patient input, may actually be a valid way to make decisions.
- Colorectal cancer screening lacks evidence of benefit
Although some studies indicate that screening with fecal occult blood testing or colonoscopy prevents deaths from colorectal cancer, the benefits may be offset by more deaths from other causes.
- Interpreting the Spine Patient Outcomes Research Trial
The Spine Patient Outcomes Research Trial compared surgical and nonsurgical treatment in patients with radicular pain. The treatments were equivalent on intention-to-treat analysis, but up to 40% of patients in each group “crossed over” to the other treatment, muddying the results.
- Modafinil in the treatment of excessive daytime sleepiness
We review the pharmacology, current approved and off-label uses, and side effects of this commonly prescribed wakefulness-promoting agent.

