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Cleveland Clinic Journal of Medicine

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    Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban
    Adewale Fawole, MD, Hamed A. Daw, MD and Mark A. Crowther, MD, MSC
    Cleveland Clinic Journal of Medicine July 2013, 80 (7) 443-451; DOI: https://doi.org/10.3949/ccjm.80a.13025

    How these new drugs work, what coagulation tests can tell us, and how to reverse the drugs’ anticoagulant effect.

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    This focal disorder of aging bone may be asymptomatic or cause pain, bowing deformities, fractures, or nonspecific rheumatic complaints.

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    Medication-assisted treatment of opiate dependence is gaining favor
    Jason M. Jerry, MD and Gregory B. Collins, MD
    Cleveland Clinic Journal of Medicine June 2013, 80 (6) 345-349; DOI: https://doi.org/10.3949/ccjm.80a.12181

    Recovering addicts are more likely to avoid returning to the use of opiates if they participate in a program that includes taking maintenance doses of methadone or buprenorphine.

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    The diagnostic evaluation should include an assessment for structural heart disease and ambulatory Holter monitoring.

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    Aspirin’s benefits in primary prevention are not as clear as in secondary prevention, particularly in people with diabetes, in women, and in the elderly.

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    Preserving fertility in female cancer patients: A snapshot of the options
    Ilaria Soave, MD, Giuseppe Lo Monte, MD, Emilio Giugliano, MD, Angela Graziano, MD and Roberto Marci, PhD
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    With the odds of surviving cancer improving, many young women facing therapy may first wish to take steps to ensure that they will still be able to bear children afterward.

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    Cleveland Clinic Journal of Medicine April 2013, 80 (4) 225-233; DOI: https://doi.org/10.3949/ccjm.80a.12182

    The emergence of carbapenem-resistant Enterobacteriaceae (CRE) highlights the importance of effective antibiotics to maintain the safety of our health care system. Clinicians will encounter CRE as a cause of difficult-to-treat and often fatal infections in hospitalized patients. We review the mechanisms of carbapenem resistance, the dissemination and clinical impact of these resistant organisms, and challenges to their detection, treatment, and control.

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    Today, patients who cannot undergo surgery can be offered a variety of less invasive treatments. We use seven cases to illustrate how to manage these patients.

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    By recognizing and measuring frailty, clinicians can better engage patients and their loved ones in difficult discussions about prognoses and plans, and can ultimately give better palliative care.

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