In Reply: Acid-base disturbances January 2017 ============================================= * Gregory W. Rutecki * Shylaja Mani We thank Dr. Emmett for his insightful comment. He is correct that in the case reported by Tan et al the elevated osmol gap was not a *direct* result of the patient’s presumed acetaminophen ingestion but more likely another unidentified toxic ingestion. The online version of our article has been modified accordingly (also see page [214](http://www.ccjm.org/lookup/volpage/84/214) of this issue). * Copyright © 2017 The Cleveland Clinic Foundation. All Rights Reserved.