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April 01, 2013; Volume 80,Issue 4
Van Duin, David
- You have accessCarbapenem-resistant Enterobacteriaceae: A menace to our most vulnerable patientsFederico Perez, MD and David Van Duin, MD, PhDCleveland Clinic Journal of Medicine April 2013, 80 (4) 225-233; DOI: https://doi.org/10.3949/ccjm.80a.12182
The emergence of carbapenem-resistant Enterobacteriaceae (CRE) highlights the importance of effective antibiotics to maintain the safety of our health care system. Clinicians will encounter CRE as a cause of difficult-to-treat and often fatal infections in hospitalized patients. We review the mechanisms of carbapenem resistance, the dissemination and clinical impact of these resistant organisms, and challenges to their detection, treatment, and control.